This story caught my eye because it immediately reminded me of Cory Doctorow’s wonderful short story, “0wnz0red”, published in his collection, A Place So Foreign and Eight More. I can never develop a good exercise habit because it always strikes me as to how pointless it is. That story is a wonderful, if fanciful, validation of that idea, that if we could only understand our own physiology well enough, we could hack it and outdo the gross mechanism of exercise by tweaking our metabolism directly.
Unfortunately, the details in the Wired story leave me a little skeptical. Even though the proven action of the drug, AICAR, in mimicking the action of AMPK in the cell tricking it into producing more energy carrying ATP, is pretty specific it does not appear to be the kind of hacking that can replace or improve on the existing action of physical exercise. Still, it may prove to be an incremental step along the way.